diff --git a/apps/browser/src/autofill/background/overlay.background.spec.ts b/apps/browser/src/autofill/background/overlay.background.spec.ts
index e7b72b72c9b..1c788e8da89 100644
--- a/apps/browser/src/autofill/background/overlay.background.spec.ts
+++ b/apps/browser/src/autofill/background/overlay.background.spec.ts
@@ -14,6 +14,7 @@ import {
 } from "@bitwarden/common/autofill/services/domain-settings.service";
 import { InlineMenuVisibilitySetting } from "@bitwarden/common/autofill/types";
 import { NeverDomains } from "@bitwarden/common/models/domain/domain-service";
+import { ConfigService } from "@bitwarden/common/platform/abstractions/config/config.service";
 import {
   EnvironmentService,
   Region,
@@ -93,6 +94,7 @@ describe("OverlayBackground", () => {
   let logService: MockProxy<LogService>;
   let cipherService: MockProxy<CipherService>;
   let autofillService: MockProxy<AutofillService>;
+  let configService: MockProxy<ConfigService>;
   let activeAccountStatusMock$: BehaviorSubject<AuthenticationStatus>;
   let authService: MockProxy<AuthService>;
   let environmentMock$: BehaviorSubject<CloudEnvironment>;
@@ -153,7 +155,7 @@ describe("OverlayBackground", () => {
     fakeStateProvider = new FakeStateProvider(accountService);
     showFaviconsMock$ = new BehaviorSubject(true);
     neverDomainsMock$ = new BehaviorSubject({});
-    domainSettingsService = new DefaultDomainSettingsService(fakeStateProvider);
+    domainSettingsService = new DefaultDomainSettingsService(fakeStateProvider, configService);
     domainSettingsService.showFavicons$ = showFaviconsMock$;
     domainSettingsService.neverDomains$ = neverDomainsMock$;
     logService = mock<LogService>();
diff --git a/apps/browser/src/autofill/deprecated/background/overlay.background.deprecated.spec.ts b/apps/browser/src/autofill/deprecated/background/overlay.background.deprecated.spec.ts
index 3adaf9e276c..86f689ad036 100644
--- a/apps/browser/src/autofill/deprecated/background/overlay.background.deprecated.spec.ts
+++ b/apps/browser/src/autofill/deprecated/background/overlay.background.deprecated.spec.ts
@@ -12,6 +12,7 @@ import {
   DefaultDomainSettingsService,
   DomainSettingsService,
 } from "@bitwarden/common/autofill/services/domain-settings.service";
+import { ConfigService } from "@bitwarden/common/platform/abstractions/config/config.service";
 import {
   EnvironmentService,
   Region,
@@ -61,6 +62,7 @@ describe("OverlayBackground", () => {
   let overlayBackground: LegacyOverlayBackground;
   const cipherService = mock<CipherService>();
   const autofillService = mock<AutofillService>();
+  let configService: MockProxy<ConfigService>;
   let activeAccountStatusMock$: BehaviorSubject<AuthenticationStatus>;
   let authService: MockProxy<AuthService>;
 
@@ -92,7 +94,7 @@ describe("OverlayBackground", () => {
   };
 
   beforeEach(() => {
-    domainSettingsService = new DefaultDomainSettingsService(fakeStateProvider);
+    domainSettingsService = new DefaultDomainSettingsService(fakeStateProvider, configService);
     activeAccountStatusMock$ = new BehaviorSubject(AuthenticationStatus.Unlocked);
     authService = mock<AuthService>();
     authService.activeAccountStatus$ = activeAccountStatusMock$;
diff --git a/apps/browser/src/autofill/popup/settings/autofill-v1.component.html b/apps/browser/src/autofill/popup/settings/autofill-v1.component.html
index 3352563f55f..1c16ee1fe12 100644
--- a/apps/browser/src/autofill/popup/settings/autofill-v1.component.html
+++ b/apps/browser/src/autofill/popup/settings/autofill-v1.component.html
@@ -255,7 +255,7 @@
       {{ "showIdentitiesCurrentTabDesc" | i18n }}
     </div>
   </div>
-  <div class="box list">
+  <div class="box list" *ngIf="blockBrowserInjectionsByDomainEnabled">
     <div class="box-content single-line">
       <button
         type="button"
diff --git a/apps/browser/src/autofill/popup/settings/autofill-v1.component.ts b/apps/browser/src/autofill/popup/settings/autofill-v1.component.ts
index 085ccba7e1e..9f015d990e9 100644
--- a/apps/browser/src/autofill/popup/settings/autofill-v1.component.ts
+++ b/apps/browser/src/autofill/popup/settings/autofill-v1.component.ts
@@ -36,6 +36,7 @@ export class AutofillV1Component implements OnInit {
   protected autoFillOverlayVisibilityOptions: any[];
   protected disablePasswordManagerLink: string;
   protected inlineMenuPositioningImprovementsEnabled: boolean = false;
+  protected blockBrowserInjectionsByDomainEnabled: boolean = false;
   protected showInlineMenuIdentities: boolean = true;
   protected showInlineMenuCards: boolean = true;
   inlineMenuIsEnabled: boolean = false;
@@ -120,6 +121,10 @@ export class AutofillV1Component implements OnInit {
       FeatureFlag.InlineMenuPositioningImprovements,
     );
 
+    this.blockBrowserInjectionsByDomainEnabled = await this.configService.getFeatureFlag(
+      FeatureFlag.BlockBrowserInjectionsByDomain,
+    );
+
     this.inlineMenuIsEnabled = this.isInlineMenuEnabled();
 
     this.showInlineMenuIdentities =
diff --git a/apps/browser/src/autofill/popup/settings/autofill.component.html b/apps/browser/src/autofill/popup/settings/autofill.component.html
index 56891c362a1..eeae0a85e3f 100644
--- a/apps/browser/src/autofill/popup/settings/autofill.component.html
+++ b/apps/browser/src/autofill/popup/settings/autofill.component.html
@@ -282,7 +282,7 @@
         </bit-form-field>
       </bit-card>
     </bit-section>
-    <bit-section>
+    <bit-section *ngIf="blockBrowserInjectionsByDomainEnabled">
       <bit-item>
         <a bit-item-content routerLink="/blocked-domains">{{ "blockedDomains" | i18n }}</a>
         <i slot="end" class="bwi bwi-angle-right bwi-lg row-sub-icon" aria-hidden="true"></i>
diff --git a/apps/browser/src/autofill/popup/settings/autofill.component.ts b/apps/browser/src/autofill/popup/settings/autofill.component.ts
index da997f550b3..884503fa360 100644
--- a/apps/browser/src/autofill/popup/settings/autofill.component.ts
+++ b/apps/browser/src/autofill/popup/settings/autofill.component.ts
@@ -49,7 +49,6 @@ import {
 
 import { BrowserApi } from "../../../platform/browser/browser-api";
 import { PopOutComponent } from "../../../platform/popup/components/pop-out.component";
-import { PopupFooterComponent } from "../../../platform/popup/layout/popup-footer.component";
 import { PopupHeaderComponent } from "../../../platform/popup/layout/popup-header.component";
 import { PopupPageComponent } from "../../../platform/popup/layout/popup-page.component";
 
@@ -67,7 +66,6 @@ import { PopupPageComponent } from "../../../platform/popup/layout/popup-page.co
     JslibModule,
     LinkModule,
     PopOutComponent,
-    PopupFooterComponent,
     PopupHeaderComponent,
     PopupPageComponent,
     RouterModule,
@@ -87,6 +85,7 @@ export class AutofillComponent implements OnInit {
   protected inlineMenuVisibility: InlineMenuVisibilitySetting =
     AutofillOverlayVisibility.OnFieldFocus;
   protected inlineMenuPositioningImprovementsEnabled: boolean = false;
+  protected blockBrowserInjectionsByDomainEnabled: boolean = false;
   protected browserClientVendor: BrowserClientVendor = BrowserClientVendors.Unknown;
   protected disablePasswordManagerURI: DisablePasswordManagerUri =
     DisablePasswordManagerUris.Unknown;
@@ -164,6 +163,10 @@ export class AutofillComponent implements OnInit {
       FeatureFlag.InlineMenuPositioningImprovements,
     );
 
+    this.blockBrowserInjectionsByDomainEnabled = await this.configService.getFeatureFlag(
+      FeatureFlag.BlockBrowserInjectionsByDomain,
+    );
+
     this.showInlineMenuIdentities =
       this.inlineMenuPositioningImprovementsEnabled &&
       (await firstValueFrom(this.autofillSettingsService.showInlineMenuIdentities$));
diff --git a/apps/browser/src/autofill/services/autofill.service.spec.ts b/apps/browser/src/autofill/services/autofill.service.spec.ts
index d3b9dfdec4d..f648631baf7 100644
--- a/apps/browser/src/autofill/services/autofill.service.spec.ts
+++ b/apps/browser/src/autofill/services/autofill.service.spec.ts
@@ -136,7 +136,7 @@ describe("AutofillService", () => {
       userNotificationsSettings,
       messageListener,
     );
-    domainSettingsService = new DefaultDomainSettingsService(fakeStateProvider);
+    domainSettingsService = new DefaultDomainSettingsService(fakeStateProvider, configService);
     domainSettingsService.equivalentDomains$ = of(mockEquivalentDomains);
     jest.spyOn(BrowserApi, "tabSendMessage");
   });
diff --git a/apps/browser/src/background/main.background.ts b/apps/browser/src/background/main.background.ts
index 618512cc51c..34c10508485 100644
--- a/apps/browser/src/background/main.background.ts
+++ b/apps/browser/src/background/main.background.ts
@@ -695,7 +695,6 @@ export default class MainBackground {
       this.vaultTimeoutSettingsService,
     );
 
-    this.domainSettingsService = new DefaultDomainSettingsService(this.stateProvider);
     this.fileUploadService = new FileUploadService(this.logService, this.apiService);
     this.cipherFileUploadService = new CipherFileUploadService(
       this.apiService,
@@ -809,6 +808,11 @@ export default class MainBackground {
       this.authService,
     );
 
+    this.domainSettingsService = new DefaultDomainSettingsService(
+      this.stateProvider,
+      this.configService,
+    );
+
     this.themeStateService = new DefaultThemeStateService(
       this.globalStateProvider,
       this.configService,
diff --git a/apps/browser/src/popup/services/services.module.ts b/apps/browser/src/popup/services/services.module.ts
index a854a14b100..92eb8973235 100644
--- a/apps/browser/src/popup/services/services.module.ts
+++ b/apps/browser/src/popup/services/services.module.ts
@@ -327,7 +327,7 @@ const safeProviders: SafeProvider[] = [
   safeProvider({
     provide: DomainSettingsService,
     useClass: DefaultDomainSettingsService,
-    deps: [StateProvider],
+    deps: [StateProvider, ConfigService],
   }),
   safeProvider({
     provide: AbstractStorageService,
diff --git a/libs/angular/src/services/jslib-services.module.ts b/libs/angular/src/services/jslib-services.module.ts
index 149d553696e..f623e9cf286 100644
--- a/libs/angular/src/services/jslib-services.module.ts
+++ b/libs/angular/src/services/jslib-services.module.ts
@@ -1246,7 +1246,7 @@ const safeProviders: SafeProvider[] = [
   safeProvider({
     provide: DomainSettingsService,
     useClass: DefaultDomainSettingsService,
-    deps: [StateProvider],
+    deps: [StateProvider, ConfigService],
   }),
   safeProvider({
     provide: BiometricStateService,
diff --git a/libs/common/src/autofill/services/domain-settings.service.ts b/libs/common/src/autofill/services/domain-settings.service.ts
index 063fa5c52a1..c49cfff6b02 100644
--- a/libs/common/src/autofill/services/domain-settings.service.ts
+++ b/libs/common/src/autofill/services/domain-settings.service.ts
@@ -1,6 +1,9 @@
 // FIXME: Update this file to be type safe and remove this and next line
 // @ts-strict-ignore
-import { map, Observable } from "rxjs";
+import { combineLatest, map, Observable } from "rxjs";
+
+import { FeatureFlag } from "@bitwarden/common/enums/feature-flag.enum";
+import { ConfigService } from "@bitwarden/common/platform/abstractions/config/config.service";
 
 import {
   NeverDomains,
@@ -81,16 +84,30 @@ export class DefaultDomainSettingsService implements DomainSettingsService {
   private defaultUriMatchStrategyState: ActiveUserState<UriMatchStrategySetting>;
   readonly defaultUriMatchStrategy$: Observable<UriMatchStrategySetting>;
 
-  constructor(private stateProvider: StateProvider) {
+  constructor(
+    private stateProvider: StateProvider,
+    private configService: ConfigService,
+  ) {
     this.showFaviconsState = this.stateProvider.getGlobal(SHOW_FAVICONS);
     this.showFavicons$ = this.showFaviconsState.state$.pipe(map((x) => x ?? true));
 
     this.neverDomainsState = this.stateProvider.getGlobal(NEVER_DOMAINS);
     this.neverDomains$ = this.neverDomainsState.state$.pipe(map((x) => x ?? null));
 
+    // Needs to be global to prevent pre-login injections
     this.blockedInteractionsUrisState = this.stateProvider.getGlobal(BLOCKED_INTERACTIONS_URIS);
-    this.blockedInteractionsUris$ = this.blockedInteractionsUrisState.state$.pipe(
-      map((x) => x ?? null),
+
+    this.blockedInteractionsUris$ = combineLatest([
+      this.blockedInteractionsUrisState.state$,
+      this.configService.getFeatureFlag$(FeatureFlag.BlockBrowserInjectionsByDomain),
+    ]).pipe(
+      map(([blockedUris, blockBrowserInjectionsByDomainEnabled]) => {
+        if (!blockBrowserInjectionsByDomainEnabled) {
+          return null;
+        }
+
+        return blockedUris ?? null;
+      }),
     );
 
     this.equivalentDomainsState = this.stateProvider.getActive(EQUIVALENT_DOMAINS);
diff --git a/libs/common/src/enums/feature-flag.enum.ts b/libs/common/src/enums/feature-flag.enum.ts
index 135119bf133..0ab7d47acfc 100644
--- a/libs/common/src/enums/feature-flag.enum.ts
+++ b/libs/common/src/enums/feature-flag.enum.ts
@@ -27,6 +27,7 @@ export enum FeatureFlag {
   SSHKeyVaultItem = "ssh-key-vault-item",
   SSHAgent = "ssh-agent",
   NotificationBarAddLoginImprovements = "notification-bar-add-login-improvements",
+  BlockBrowserInjectionsByDomain = "block-browser-injections-by-domain",
   AC2476_DeprecateStripeSourcesAPI = "AC-2476-deprecate-stripe-sources-api",
   CipherKeyEncryption = "cipher-key-encryption",
   VerifiedSsoDomainEndpoint = "pm-12337-refactor-sso-details-endpoint",
@@ -81,6 +82,7 @@ export const DefaultFeatureFlagValue = {
   [FeatureFlag.SSHKeyVaultItem]: FALSE,
   [FeatureFlag.SSHAgent]: FALSE,
   [FeatureFlag.NotificationBarAddLoginImprovements]: FALSE,
+  [FeatureFlag.BlockBrowserInjectionsByDomain]: FALSE,
   [FeatureFlag.AC2476_DeprecateStripeSourcesAPI]: FALSE,
   [FeatureFlag.CipherKeyEncryption]: FALSE,
   [FeatureFlag.VerifiedSsoDomainEndpoint]: FALSE,