diff --git a/apps/browser/src/autofill/content/components/buttons/action-button.ts b/apps/browser/src/autofill/content/components/buttons/action-button.ts
index 73fc1e79ec5..68100512511 100644
--- a/apps/browser/src/autofill/content/components/buttons/action-button.ts
+++ b/apps/browser/src/autofill/content/components/buttons/action-button.ts
@@ -26,7 +26,7 @@ export function ActionButton({
   fullWidth = true,
 }: ActionButtonProps) {
   const handleButtonClick = (event: Event) => {
-    if (!disabled && !isLoading) {
+    if (event.isTrusted && !disabled && !isLoading) {
       handleClick(event);
     }
   };
diff --git a/apps/browser/src/autofill/content/components/buttons/badge-button.ts b/apps/browser/src/autofill/content/components/buttons/badge-button.ts
index 3cdd453ee1a..c4efa87cd1d 100644
--- a/apps/browser/src/autofill/content/components/buttons/badge-button.ts
+++ b/apps/browser/src/autofill/content/components/buttons/badge-button.ts
@@ -23,7 +23,7 @@ export function BadgeButton({
   username,
 }: BadgeButtonProps) {
   const handleButtonClick = (event: Event) => {
-    if (!disabled) {
+    if (event.isTrusted && !disabled) {
       buttonAction(event);
     }
   };
diff --git a/apps/browser/src/autofill/content/components/buttons/edit-button.ts b/apps/browser/src/autofill/content/components/buttons/edit-button.ts
index ecbb736bb8e..147d244a0d6 100644
--- a/apps/browser/src/autofill/content/components/buttons/edit-button.ts
+++ b/apps/browser/src/autofill/content/components/buttons/edit-button.ts
@@ -21,7 +21,7 @@ export function EditButton({ buttonAction, buttonText, disabled = false, theme }
       aria-label=${buttonText}
       class=${editButtonStyles({ disabled, theme })}
       @click=${(event: Event) => {
-        if (!disabled) {
+        if (event.isTrusted && !disabled) {
           buttonAction(event);
         }
       }}
diff --git a/apps/browser/src/autofill/content/components/cipher/cipher-action.ts b/apps/browser/src/autofill/content/components/cipher/cipher-action.ts
index 7a392849996..9674370abe8 100644
--- a/apps/browser/src/autofill/content/components/cipher/cipher-action.ts
+++ b/apps/browser/src/autofill/content/components/cipher/cipher-action.ts
@@ -28,6 +28,10 @@ export function CipherAction({
   username,
 }: CipherActionProps) {
   const selectCipherHandleAction = (e: Event) => {
+    if (!e.isTrusted) {
+      return;
+    }
+
     selectedCipherSignal.set(cipherId);
     try {
       handleAction(e);
diff --git a/apps/browser/src/autofill/content/components/notification/confirmation/message.ts b/apps/browser/src/autofill/content/components/notification/confirmation/message.ts
index 36ea9c1f9d6..0fa35db3587 100644
--- a/apps/browser/src/autofill/content/components/notification/confirmation/message.ts
+++ b/apps/browser/src/autofill/content/components/notification/confirmation/message.ts
@@ -127,7 +127,7 @@ const AdditionalMessageStyles = ({ theme }: { theme: Theme }) => css`
 `;
 
 function handleButtonKeyDown(event: KeyboardEvent, handleClick: () => void) {
-  if (event.key === "Enter" || event.key === " ") {
+  if (event.isTrusted && (event.key === "Enter" || event.key === " ")) {
     event.preventDefault();
     handleClick();
   }
diff --git a/apps/browser/src/autofill/content/components/option-selection/option-item.ts b/apps/browser/src/autofill/content/components/option-selection/option-item.ts
index 6af6a2d6538..cd0027cad03 100644
--- a/apps/browser/src/autofill/content/components/option-selection/option-item.ts
+++ b/apps/browser/src/autofill/content/components/option-selection/option-item.ts
@@ -29,6 +29,10 @@ export function OptionItem({
   handleSelection,
 }: OptionItemProps) {
   const handleSelectionKeyUpProxy = (event: KeyboardEvent) => {
+    if (!event.isTrusted) {
+      return;
+    }
+
     const listenedForKeys = new Set(["Enter", "Space"]);
     if (listenedForKeys.has(event.code) && event.target instanceof Element) {
       handleSelection();
diff --git a/apps/browser/src/autofill/content/components/option-selection/option-items.ts b/apps/browser/src/autofill/content/components/option-selection/option-items.ts
index 58216b6c1b2..0f592a01343 100644
--- a/apps/browser/src/autofill/content/components/option-selection/option-items.ts
+++ b/apps/browser/src/autofill/content/components/option-selection/option-items.ts
@@ -57,6 +57,10 @@ export function OptionItems({
 }
 
 function handleMenuKeyUp(event: KeyboardEvent) {
+  if (!event.isTrusted) {
+    return;
+  }
+
   const items = [
     ...(event.currentTarget as HTMLElement).querySelectorAll<HTMLElement>('[tabindex="0"]'),
   ];
diff --git a/apps/browser/src/autofill/content/components/option-selection/option-selection.ts b/apps/browser/src/autofill/content/components/option-selection/option-selection.ts
index ee711456e9c..95bd915ce23 100644
--- a/apps/browser/src/autofill/content/components/option-selection/option-selection.ts
+++ b/apps/browser/src/autofill/content/components/option-selection/option-selection.ts
@@ -54,7 +54,7 @@ export class OptionSelection extends LitElement {
   private static currentOpenInstance: OptionSelection | null = null;
 
   private handleButtonClick = async (event: Event) => {
-    if (!this.disabled) {
+    if (event.isTrusted && !this.disabled) {
       const isOpening = !this.showMenu;
 
       if (isOpening) {
diff --git a/apps/browser/src/autofill/overlay/inline-menu/pages/list/autofill-inline-menu-list.ts b/apps/browser/src/autofill/overlay/inline-menu/pages/list/autofill-inline-menu-list.ts
index c680fe4745c..ab1683e2536 100644
--- a/apps/browser/src/autofill/overlay/inline-menu/pages/list/autofill-inline-menu-list.ts
+++ b/apps/browser/src/autofill/overlay/inline-menu/pages/list/autofill-inline-menu-list.ts
@@ -194,7 +194,11 @@ export class AutofillInlineMenuList extends AutofillInlineMenuPageElement {
 
   private handleSaveLoginInlineMenuKeyUp = (event: KeyboardEvent) => {
     const listenedForKeys = new Set(["ArrowDown"]);
-    if (!listenedForKeys.has(event.code) || !(event.target instanceof Element)) {
+    if (
+      !event.isTrusted ||
+      !listenedForKeys.has(event.code) ||
+      !(event.target instanceof Element)
+    ) {
       return;
     }
 
@@ -353,7 +357,7 @@ export class AutofillInlineMenuList extends AutofillInlineMenuPageElement {
    * @param event - The keyup event.
    */
   private handleFillGeneratedPasswordKeyUp = (event: KeyboardEvent) => {
-    if (event.ctrlKey || event.altKey || event.metaKey || event.shiftKey) {
+    if (!event.isTrusted || event.ctrlKey || event.altKey || event.metaKey || event.shiftKey) {
       return;
     }
 
@@ -394,7 +398,7 @@ export class AutofillInlineMenuList extends AutofillInlineMenuPageElement {
    * @param event - The keyup event.
    */
   private handleRefreshGeneratedPasswordKeyUp = (event: KeyboardEvent) => {
-    if (event.ctrlKey || event.altKey || event.metaKey || event.shiftKey) {
+    if (!event.isTrusted || event.ctrlKey || event.altKey || event.metaKey || event.shiftKey) {
       return;
     }
 
@@ -974,7 +978,11 @@ export class AutofillInlineMenuList extends AutofillInlineMenuPageElement {
    */
   private handleFillCipherKeyUpEvent = (event: KeyboardEvent) => {
     const listenedForKeys = new Set(["ArrowDown", "ArrowUp", "ArrowRight"]);
-    if (!listenedForKeys.has(event.code) || !(event.target instanceof Element)) {
+    if (
+      !event.isTrusted ||
+      !listenedForKeys.has(event.code) ||
+      !(event.target instanceof Element)
+    ) {
       return;
     }
 
@@ -1002,7 +1010,11 @@ export class AutofillInlineMenuList extends AutofillInlineMenuPageElement {
    */
   private handleNewItemButtonKeyUpEvent = (event: KeyboardEvent) => {
     const listenedForKeys = new Set(["ArrowDown", "ArrowUp"]);
-    if (!listenedForKeys.has(event.code) || !(event.target instanceof Element)) {
+    if (
+      !event.isTrusted ||
+      !listenedForKeys.has(event.code) ||
+      !(event.target instanceof Element)
+    ) {
       return;
     }
 
@@ -1064,7 +1076,11 @@ export class AutofillInlineMenuList extends AutofillInlineMenuPageElement {
    */
   private handleViewCipherKeyUpEvent = (event: KeyboardEvent) => {
     const listenedForKeys = new Set(["ArrowDown", "ArrowUp", "ArrowLeft"]);
-    if (!listenedForKeys.has(event.code) || !(event.target instanceof Element)) {
+    if (
+      !event.isTrusted ||
+      !listenedForKeys.has(event.code) ||
+      !(event.target instanceof Element)
+    ) {
       return;
     }
 
diff --git a/apps/browser/src/autofill/overlay/inline-menu/pages/shared/autofill-inline-menu-page-element.ts b/apps/browser/src/autofill/overlay/inline-menu/pages/shared/autofill-inline-menu-page-element.ts
index 5df6e7cd190..32df5e4cb34 100644
--- a/apps/browser/src/autofill/overlay/inline-menu/pages/shared/autofill-inline-menu-page-element.ts
+++ b/apps/browser/src/autofill/overlay/inline-menu/pages/shared/autofill-inline-menu-page-element.ts
@@ -163,7 +163,7 @@ export class AutofillInlineMenuPageElement extends HTMLElement {
    */
   private handleDocumentKeyDownEvent = (event: KeyboardEvent) => {
     const listenedForKeys = new Set(["Tab", "Escape", "ArrowUp", "ArrowDown"]);
-    if (!listenedForKeys.has(event.code)) {
+    if (!event.isTrusted || !listenedForKeys.has(event.code)) {
       return;
     }
 
diff --git a/apps/browser/src/autofill/services/autofill-overlay-content.service.ts b/apps/browser/src/autofill/services/autofill-overlay-content.service.ts
index fcd4a289220..861929a14de 100644
--- a/apps/browser/src/autofill/services/autofill-overlay-content.service.ts
+++ b/apps/browser/src/autofill/services/autofill-overlay-content.service.ts
@@ -618,6 +618,7 @@ export class AutofillOverlayContentService implements AutofillOverlayContentServ
    */
   private handleSubmitButtonInteraction = (event: PointerEvent) => {
     if (
+      !event.isTrusted ||
       !this.submitElements.has(event.target as HTMLElement) ||
       (event.type === "keyup" &&
         !["Enter", "Space"].includes((event as unknown as KeyboardEvent).code))