diff --git a/apps/browser/src/autofill/browser/abstractions/main-context-menu-handler.ts b/apps/browser/src/autofill/browser/abstractions/main-context-menu-handler.ts
index 7ded23116ee..180a4685332 100644
--- a/apps/browser/src/autofill/browser/abstractions/main-context-menu-handler.ts
+++ b/apps/browser/src/autofill/browser/abstractions/main-context-menu-handler.ts
@@ -1,5 +1,6 @@
 type InitContextMenuItems = Omit<chrome.contextMenus.CreateProperties, "contexts"> & {
-  checkPremiumAccess?: boolean;
+  requiresPremiumAccess?: boolean;
+  requiresUnblockedUri?: boolean;
 };
 
 export { InitContextMenuItems };
diff --git a/apps/browser/src/autofill/browser/cipher-context-menu-handler.ts b/apps/browser/src/autofill/browser/cipher-context-menu-handler.ts
index 038f4e85c9a..e2bf75350a2 100644
--- a/apps/browser/src/autofill/browser/cipher-context-menu-handler.ts
+++ b/apps/browser/src/autofill/browser/cipher-context-menu-handler.ts
@@ -21,7 +21,7 @@ export class CipherContextMenuHandler {
     private accountService: AccountService,
   ) {}
 
-  async update(url: string) {
+  async update(url: string, currentUriIsBlocked: boolean = false) {
     if (this.mainContextMenuHandler.initRunning) {
       return;
     }
@@ -88,6 +88,10 @@ export class CipherContextMenuHandler {
     for (const cipher of ciphers) {
       await this.updateForCipher(cipher);
     }
+
+    if (currentUriIsBlocked) {
+      await this.mainContextMenuHandler.removeBlockedUriMenuItems();
+    }
   }
 
   private async updateForCipher(cipher: CipherView) {
diff --git a/apps/browser/src/autofill/browser/main-context-menu-handler.spec.ts b/apps/browser/src/autofill/browser/main-context-menu-handler.spec.ts
index 79998b65205..267a832a671 100644
--- a/apps/browser/src/autofill/browser/main-context-menu-handler.spec.ts
+++ b/apps/browser/src/autofill/browser/main-context-menu-handler.spec.ts
@@ -2,7 +2,17 @@ import { mock, MockProxy } from "jest-mock-extended";
 import { of } from "rxjs";
 
 import { AccountService } from "@bitwarden/common/auth/abstractions/account.service";
-import { NOOP_COMMAND_SUFFIX } from "@bitwarden/common/autofill/constants";
+import {
+  AUTOFILL_CARD_ID,
+  AUTOFILL_ID,
+  AUTOFILL_IDENTITY_ID,
+  COPY_IDENTIFIER_ID,
+  COPY_PASSWORD_ID,
+  COPY_USERNAME_ID,
+  COPY_VERIFICATION_CODE_ID,
+  NOOP_COMMAND_SUFFIX,
+  SEPARATOR_ID,
+} from "@bitwarden/common/autofill/constants";
 import { AutofillSettingsServiceAbstraction } from "@bitwarden/common/autofill/services/autofill-settings.service";
 import { BillingAccountProfileStateService } from "@bitwarden/common/billing/abstractions/account/billing-account-profile-state.service";
 import { I18nService } from "@bitwarden/common/platform/abstractions/i18n.service";
@@ -15,6 +25,43 @@ import { CipherView } from "@bitwarden/common/vault/models/view/cipher.view";
 
 import { MainContextMenuHandler } from "./main-context-menu-handler";
 
+/**
+ * Used in place of Set method `symmetricDifference`, which is only available to node version 22.0.0 or greater:
+ * https://developer.mozilla.org/en-US/docs/Web/JavaScript/Reference/Global_Objects/Set/symmetricDifference
+ */
+function symmetricDifference(setA: Set<string>, setB: Set<string>) {
+  const _difference = new Set(setA);
+  for (const elem of setB) {
+    if (_difference.has(elem)) {
+      _difference.delete(elem);
+    } else {
+      _difference.add(elem);
+    }
+  }
+  return _difference;
+}
+
+const createCipher = (data?: {
+  id?: CipherView["id"];
+  username?: CipherView["login"]["username"];
+  password?: CipherView["login"]["password"];
+  totp?: CipherView["login"]["totp"];
+  viewPassword?: CipherView["viewPassword"];
+}): CipherView => {
+  const { id, username, password, totp, viewPassword } = data || {};
+  const cipherView = new CipherView(
+    new Cipher({
+      id: id ?? "1",
+      type: CipherType.Login,
+      viewPassword: viewPassword ?? true,
+    } as any),
+  );
+  cipherView.login.username = username ?? "USERNAME";
+  cipherView.login.password = password ?? "PASSWORD";
+  cipherView.login.totp = totp ?? "TOTP";
+  return cipherView;
+};
+
 describe("context-menu", () => {
   let stateService: MockProxy<StateService>;
   let autofillSettingsService: MockProxy<AutofillSettingsServiceAbstraction>;
@@ -59,6 +106,9 @@ describe("context-menu", () => {
       billingAccountProfileStateService,
       accountService,
     );
+
+    jest.spyOn(MainContextMenuHandler, "remove");
+
     autofillSettingsService.enableContextMenu$ = of(true);
     accountService.activeAccount$ = of({
       id: "userId" as UserId,
@@ -68,7 +118,10 @@ describe("context-menu", () => {
     });
   });
 
-  afterEach(() => jest.resetAllMocks());
+  afterEach(async () => {
+    await MainContextMenuHandler.removeAll();
+    jest.resetAllMocks();
+  });
 
   describe("init", () => {
     it("has menu disabled", async () => {
@@ -97,27 +150,6 @@ describe("context-menu", () => {
   });
 
   describe("loadOptions", () => {
-    const createCipher = (data?: {
-      id?: CipherView["id"];
-      username?: CipherView["login"]["username"];
-      password?: CipherView["login"]["password"];
-      totp?: CipherView["login"]["totp"];
-      viewPassword?: CipherView["viewPassword"];
-    }): CipherView => {
-      const { id, username, password, totp, viewPassword } = data || {};
-      const cipherView = new CipherView(
-        new Cipher({
-          id: id ?? "1",
-          type: CipherType.Login,
-          viewPassword: viewPassword ?? true,
-        } as any),
-      );
-      cipherView.login.username = username ?? "USERNAME";
-      cipherView.login.password = password ?? "PASSWORD";
-      cipherView.login.totp = totp ?? "TOTP";
-      return cipherView;
-    };
-
     it("is not a login cipher", async () => {
       await sut.loadOptions("TEST_TITLE", "1", {
         ...createCipher(),
@@ -128,33 +160,124 @@ describe("context-menu", () => {
     });
 
     it("creates item for autofill", async () => {
-      await sut.loadOptions(
-        "TEST_TITLE",
-        "1",
-        createCipher({
-          username: "",
-          totp: "",
-          viewPassword: false,
-        }),
+      const cipher = createCipher({
+        username: "",
+        totp: "",
+        viewPassword: true,
+      });
+      const optionId = "1";
+      await sut.loadOptions("TEST_TITLE", optionId, cipher);
+
+      expect(createSpy).toHaveBeenCalledTimes(2);
+
+      expect(MainContextMenuHandler["existingMenuItems"].size).toEqual(2);
+
+      const expectedMenuItems = new Set([
+        AUTOFILL_ID + `_${optionId}`,
+        COPY_PASSWORD_ID + `_${optionId}`,
+      ]);
+
+      // @TODO Replace with `symmetricDifference` Set method once node 22.0.0 or higher is used
+      // const expectedReceivedDiff = expectedMenuItems.symmetricDifference(MainContextMenuHandler["existingMenuItems"])
+      const expectedReceivedDiff = symmetricDifference(
+        expectedMenuItems,
+        MainContextMenuHandler["existingMenuItems"],
       );
 
-      expect(createSpy).toHaveBeenCalledTimes(1);
+      expect(expectedReceivedDiff.size).toEqual(0);
     });
 
     it("create entry for each cipher piece", async () => {
       billingAccountProfileStateService.hasPremiumFromAnySource$.mockReturnValue(of(true));
-
-      await sut.loadOptions("TEST_TITLE", "1", createCipher());
+      const optionId = "arbitraryString";
+      await sut.loadOptions("TEST_TITLE", optionId, createCipher());
 
       expect(createSpy).toHaveBeenCalledTimes(4);
+
+      expect(MainContextMenuHandler["existingMenuItems"].size).toEqual(4);
+
+      const expectedMenuItems = new Set([
+        AUTOFILL_ID + `_${optionId}`,
+        COPY_PASSWORD_ID + `_${optionId}`,
+        COPY_USERNAME_ID + `_${optionId}`,
+        COPY_VERIFICATION_CODE_ID + `_${optionId}`,
+      ]);
+
+      // @TODO Replace with `symmetricDifference` Set method once node 22.0.0 or higher is used
+      // const expectedReceivedDiff = expectedMenuItems.symmetricDifference(MainContextMenuHandler["existingMenuItems"])
+      const expectedReceivedDiff = symmetricDifference(
+        expectedMenuItems,
+        MainContextMenuHandler["existingMenuItems"],
+      );
+
+      expect(expectedReceivedDiff.size).toEqual(0);
     });
 
     it("creates a login/unlock item for each context menu action option when user is not authenticated", async () => {
       billingAccountProfileStateService.hasPremiumFromAnySource$.mockReturnValue(of(true));
 
-      await sut.loadOptions("TEST_TITLE", "NOOP");
+      const optionId = "NOOP";
+      await sut.loadOptions("TEST_TITLE", optionId);
 
       expect(createSpy).toHaveBeenCalledTimes(6);
+
+      expect(MainContextMenuHandler["existingMenuItems"].size).toEqual(6);
+
+      const expectedMenuItems = new Set([
+        AUTOFILL_ID + `_${optionId}`,
+        COPY_PASSWORD_ID + `_${optionId}`,
+        COPY_USERNAME_ID + `_${optionId}`,
+        COPY_VERIFICATION_CODE_ID + `_${optionId}`,
+        AUTOFILL_CARD_ID + `_${optionId}`,
+        AUTOFILL_IDENTITY_ID + `_${optionId}`,
+      ]);
+
+      // @TODO Replace with `symmetricDifference` Set method once node 22.0.0 or higher is used
+      // const expectedReceivedDiff = expectedMenuItems.symmetricDifference(MainContextMenuHandler["existingMenuItems"])
+      const expectedReceivedDiff = symmetricDifference(
+        expectedMenuItems,
+        MainContextMenuHandler["existingMenuItems"],
+      );
+
+      expect(expectedReceivedDiff.size).toEqual(0);
+    });
+  });
+
+  describe("removeBlockedUriMenuItems", () => {
+    it("removes menu items that require code injection", async () => {
+      billingAccountProfileStateService.hasPremiumFromAnySource$.mockReturnValue(of(true));
+      autofillSettingsService.enableContextMenu$ = of(true);
+      stateService.getIsAuthenticated.mockResolvedValue(true);
+
+      const optionId = "1";
+      await sut.loadOptions("TEST_TITLE", optionId, createCipher());
+
+      await sut.removeBlockedUriMenuItems();
+
+      expect(MainContextMenuHandler["remove"]).toHaveBeenCalledTimes(5);
+      expect(MainContextMenuHandler["remove"]).toHaveBeenCalledWith(AUTOFILL_ID);
+      expect(MainContextMenuHandler["remove"]).toHaveBeenCalledWith(AUTOFILL_IDENTITY_ID);
+      expect(MainContextMenuHandler["remove"]).toHaveBeenCalledWith(AUTOFILL_CARD_ID);
+      expect(MainContextMenuHandler["remove"]).toHaveBeenCalledWith(SEPARATOR_ID + 2);
+      expect(MainContextMenuHandler["remove"]).toHaveBeenCalledWith(COPY_IDENTIFIER_ID);
+
+      expect(MainContextMenuHandler["existingMenuItems"].size).toEqual(4);
+
+      const expectedMenuItems = new Set([
+        AUTOFILL_ID + `_${optionId}`,
+        COPY_PASSWORD_ID + `_${optionId}`,
+        COPY_USERNAME_ID + `_${optionId}`,
+        COPY_VERIFICATION_CODE_ID + `_${optionId}`,
+      ]);
+
+      // @TODO Replace with `symmetricDifference` Set method once node 22.0.0 or higher is used
+      // const expectedReceivedDiff = expectedMenuItems.symmetricDifference(MainContextMenuHandler["existingMenuItems"])
+      const expectedReceivedDiff = symmetricDifference(
+        expectedMenuItems,
+        MainContextMenuHandler["existingMenuItems"],
+      );
+
+      expect(expectedReceivedDiff.size).toEqual(0);
     });
   });
 
diff --git a/apps/browser/src/autofill/browser/main-context-menu-handler.ts b/apps/browser/src/autofill/browser/main-context-menu-handler.ts
index 41d88439e8f..ad9dc34e501 100644
--- a/apps/browser/src/autofill/browser/main-context-menu-handler.ts
+++ b/apps/browser/src/autofill/browser/main-context-menu-handler.ts
@@ -31,6 +31,7 @@ import { CipherView } from "@bitwarden/common/vault/models/view/cipher.view";
 import { InitContextMenuItems } from "./abstractions/main-context-menu-handler";
 
 export class MainContextMenuHandler {
+  static existingMenuItems: Set<string> = new Set();
   initRunning = false;
   private initContextMenuItems: InitContextMenuItems[] = [
     {
@@ -41,6 +42,7 @@ export class MainContextMenuHandler {
       id: AUTOFILL_ID,
       parentId: ROOT_ID,
       title: this.i18nService.t("autoFillLogin"),
+      requiresUnblockedUri: true,
     },
     {
       id: COPY_USERNAME_ID,
@@ -56,7 +58,7 @@ export class MainContextMenuHandler {
       id: COPY_VERIFICATION_CODE_ID,
       parentId: ROOT_ID,
       title: this.i18nService.t("copyVerificationCode"),
-      checkPremiumAccess: true,
+      requiresPremiumAccess: true,
     },
     {
       id: SEPARATOR_ID + 1,
@@ -67,16 +69,19 @@ export class MainContextMenuHandler {
       id: AUTOFILL_IDENTITY_ID,
       parentId: ROOT_ID,
       title: this.i18nService.t("autoFillIdentity"),
+      requiresUnblockedUri: true,
     },
     {
       id: AUTOFILL_CARD_ID,
       parentId: ROOT_ID,
       title: this.i18nService.t("autoFillCard"),
+      requiresUnblockedUri: true,
     },
     {
       id: SEPARATOR_ID + 2,
       type: "separator",
       parentId: ROOT_ID,
+      requiresUnblockedUri: true,
     },
     {
       id: GENERATE_PASSWORD_ID,
@@ -87,6 +92,7 @@ export class MainContextMenuHandler {
       id: COPY_IDENTIFIER_ID,
       parentId: ROOT_ID,
       title: this.i18nService.t("copyElementIdentifier"),
+      requiresUnblockedUri: true,
     },
   ];
   private noCardsContextMenuItems: chrome.contextMenus.CreateProperties[] = [
@@ -175,13 +181,19 @@ export class MainContextMenuHandler {
         this.billingAccountProfileStateService.hasPremiumFromAnySource$(account.id),
       );
 
-      for (const options of this.initContextMenuItems) {
-        if (options.checkPremiumAccess && !hasPremium) {
+      for (const menuItem of this.initContextMenuItems) {
+        const {
+          requiresPremiumAccess,
+          // eslint-disable-next-line @typescript-eslint/no-unused-vars
+          requiresUnblockedUri, // destructuring this out of being passed to `create`
+          ...otherOptions
+        } = menuItem;
+
+        if (requiresPremiumAccess && !hasPremium) {
           continue;
         }
 
-        delete options.checkPremiumAccess;
-        await MainContextMenuHandler.create({ ...options, contexts: ["all"] });
+        await MainContextMenuHandler.create({ ...otherOptions, contexts: ["all"] });
       }
     } catch (error) {
       this.logService.warning(error.message);
@@ -202,12 +214,16 @@ export class MainContextMenuHandler {
     }
 
     return new Promise<void>((resolve, reject) => {
-      chrome.contextMenus.create(options, () => {
+      const itemId = chrome.contextMenus.create(options, () => {
         if (chrome.runtime.lastError) {
           return reject(chrome.runtime.lastError);
         }
         resolve();
       });
+
+      this.existingMenuItems.add(`${itemId}`);
+
+      return itemId;
     });
   };
 
@@ -221,12 +237,16 @@ export class MainContextMenuHandler {
 
         resolve();
       });
+
+      this.existingMenuItems = new Set();
+
+      return;
     });
   }
 
   static remove(menuItemId: string) {
     return new Promise<void>((resolve, reject) => {
-      chrome.contextMenus.remove(menuItemId, () => {
+      const itemId = chrome.contextMenus.remove(menuItemId, () => {
         if (chrome.runtime.lastError) {
           reject(chrome.runtime.lastError);
           return;
@@ -234,6 +254,10 @@ export class MainContextMenuHandler {
 
         resolve();
       });
+
+      this.existingMenuItems.delete(`${itemId}`);
+
+      return;
     });
   }
 
@@ -244,6 +268,11 @@ export class MainContextMenuHandler {
       const createChildItem = async (parentId: string) => {
         const menuItemId = `${parentId}_${optionId}`;
 
+        const itemAlreadyExists = MainContextMenuHandler.existingMenuItems.has(menuItemId);
+        if (itemAlreadyExists) {
+          return;
+        }
+
         return await MainContextMenuHandler.create({
           type: "normal",
           id: menuItemId,
@@ -255,10 +284,18 @@ export class MainContextMenuHandler {
 
       if (
         !cipher ||
-        (cipher.type === CipherType.Login && !Utils.isNullOrEmpty(cipher.login?.password))
+        (cipher.type === CipherType.Login &&
+          (!Utils.isNullOrEmpty(cipher.login?.username) ||
+            !Utils.isNullOrEmpty(cipher.login?.password) ||
+            !Utils.isNullOrEmpty(cipher.login?.totp)))
       ) {
         await createChildItem(AUTOFILL_ID);
+      }
 
+      if (
+        !cipher ||
+        (cipher.type === CipherType.Login && !Utils.isNullOrEmpty(cipher.login?.password))
+      ) {
         if (cipher?.viewPassword ?? true) {
           await createChildItem(COPY_PASSWORD_ID);
         }
@@ -305,10 +342,22 @@ export class MainContextMenuHandler {
     }
   }
 
+  async removeBlockedUriMenuItems() {
+    try {
+      for (const menuItem of this.initContextMenuItems) {
+        if (menuItem.requiresUnblockedUri && menuItem.id) {
+          await MainContextMenuHandler.remove(menuItem.id);
+        }
+      }
+    } catch (error) {
+      this.logService.warning(error.message);
+    }
+  }
+
   async noCards() {
     try {
-      for (const option of this.noCardsContextMenuItems) {
-        await MainContextMenuHandler.create(option);
+      for (const menuItem of this.noCardsContextMenuItems) {
+        await MainContextMenuHandler.create(menuItem);
       }
     } catch (error) {
       this.logService.warning(error.message);
@@ -317,8 +366,8 @@ export class MainContextMenuHandler {
 
   async noIdentities() {
     try {
-      for (const option of this.noIdentitiesContextMenuItems) {
-        await MainContextMenuHandler.create(option);
+      for (const menuItem of this.noIdentitiesContextMenuItems) {
+        await MainContextMenuHandler.create(menuItem);
       }
     } catch (error) {
       this.logService.warning(error.message);
@@ -327,8 +376,8 @@ export class MainContextMenuHandler {
 
   async noLogins() {
     try {
-      for (const option of this.noLoginsContextMenuItems) {
-        await MainContextMenuHandler.create(option);
+      for (const menuItem of this.noLoginsContextMenuItems) {
+        await MainContextMenuHandler.create(menuItem);
       }
 
       await this.loadOptions(this.i18nService.t("addLoginMenu"), CREATE_LOGIN_ID);
diff --git a/apps/browser/src/background/main.background.ts b/apps/browser/src/background/main.background.ts
index d2b51c7ef40..1c6d018a82c 100644
--- a/apps/browser/src/background/main.background.ts
+++ b/apps/browser/src/background/main.background.ts
@@ -1374,17 +1374,41 @@ export default class MainBackground {
       return;
     }
 
-    await this.mainContextMenuHandler?.init();
+    const contextMenuIsEnabled = await this.mainContextMenuHandler?.init();
+    if (!contextMenuIsEnabled) {
+      this.onUpdatedRan = this.onReplacedRan = false;
+      return;
+    }
 
     const tab = await BrowserApi.getTabFromCurrentWindow();
+
     if (tab) {
-      await this.cipherContextMenuHandler?.update(tab.url);
+      const currentUriIsBlocked = await firstValueFrom(
+        this.domainSettingsService.blockedInteractionsUris$.pipe(
+          map((blockedInteractionsUris) => {
+            if (blockedInteractionsUris && tab?.url?.length) {
+              const tabURL = new URL(tab.url);
+              const tabIsBlocked = Object.keys(blockedInteractionsUris).some((blockedHostname) =>
+                tabURL.hostname.endsWith(blockedHostname),
+              );
+
+              if (tabIsBlocked) {
+                return true;
+              }
+            }
+
+            return false;
+          }),
+        ),
+      );
+
+      await this.cipherContextMenuHandler?.update(tab.url, currentUriIsBlocked);
       this.onUpdatedRan = this.onReplacedRan = false;
     }
   }
 
   async updateOverlayCiphers() {
-    // overlayBackground null in popup only contexts
+    // `overlayBackground` is null in popup only contexts
     if (this.overlayBackground) {
       await this.overlayBackground.updateOverlayCiphers();
     }